Norfentanyl Rapid Test

Intended Use

Norfentanyl Rapid Test (Urine) is a rapid visual immunoassay for the qualitative presumptive detection of norfentanyl in human urine specimens at the cut-off concentrations.

Introduction

Fentanyl is a synthetic opioid related to the phenylpiperidines. Fentanyl is approximately 100 times more potent than morphine. This agent is highly lipid soluble and rapidly cross the blood-brain barrier. This is reflected in the half-life for equilibration between the plasma and cerebrospinal fluid of approximately 5 minutes for fentanyl. The levels in plasma and cerebrospinal fluid decline rapidly owing to redistribution of fentanyl from highly perfused tissue groups to other tissues, such as muscle and fat. As saturation of less well-perfused tissue occurs, the duration of effect of fentanyl and sufentanil approaches the length of their elimination half-lives of between 3 and 4 hours. Fentanyl undergoes hepatic metabolism and renal excretion. Therefore, with the use of higher doses or prolonged infusions, fentanyl becomes longer acting.

Principle

Norfentanyl Rapid Test (Urine) (Urine) has been designed to detect norfentanyl and other opiates through visual interpretation of color development in the strip. The membrane was immobilized with norfentanyl conjugates on the test region, and the sample pad was pre-coated with colored anti- norfentanyl antibodies colloidal gold conjugates. After specimens were added, the gold-conjugates move along the membrane chromatographically by capillary action and antibodies get to the test region. If there is no drug molecule in the urine the antibody gold conjugate would attach to the drug conjugate to form a visible line. Therefore, the formation of a visible precipitant in the test region occurs when the urine is negative for the drug. If norfentanyl are present in the urine, the drug antigen competes with the immobilized drug conjugate on the test region for limited antibody sites. In case of sufficient concentration of the drug, it fills the limited antibody binding sites. This will prevent attachment of the colored antibody-colloidal gold conjugate to the drug conjugate zone on the test region. Therefore, absence of the colored band on the test region indicates a positive result. Appearance of a colored band at the control region serves as a procedural control. This indicates that proper volume of specimen has been added and membrane wicking has occurred.

Test Procedure

The NFYL Rapid Test Strip (Urine)

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