Acetaminophen Rapid Test

Intended Use

Acetaminophen Rapid Test is a lateral flow chromatographic immunoassay for the detection of Acetaminophen in human urine at a level relative to the Acetaminophen cut-off concentration of 5 µg/ mL.

Introduction

Acetaminophen (paracetamol) is a popular alternative to aspirin due to its lower potential for undesirable side effects, exhibiting analgesic and antipyretic effect without anti-inflammatory properties. Acetaminophen is available in pure form as numerous tradename preparations for oral use, in amounts of 350-500 mg in normal-release or 650 mg in sustained release formulations. Its is also found combined in over 200 preparations with other drugs such as codeine, hydrocodone and propoxyphene.

In therapeutic usage the drug is excreted largely in the urine as various conjugates: 45-55% as a glucuronide conjugate, 20-30% as a sulfate, and 15-55% as cysteine and mercapturic acid conjugates. Approximately 2% of each doses is excreted unchanged in the urine. Following overdosage, saturation of conjugation pathways occurs and glutathione stores become depleted, resulting in the formation of a highly reactive acetaminophen metabolite. The amount of unchanged acetaminophen excreted in urine after overdosage may increase to as much as 10-14% of each dose.

Test Procedure

Acetaminophen Rapid Test Strip (Urine)

Acetaminophen Rapid Test Device (Urine)

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