NT-proBNP Rapid Test

Intended Use

NT-proBNP Rapid Test Device (Whole Blood/Serum/Plasma) is a rapid immunochormatographic assay for the qualitative detection of NT-proBNP in human whole blood, serum or plasma specimens. The test is an in vitro diagnostic device intended for use as an aid for the diagnosis of heart failure.

Introduction

N-terminal pro-brain (or B-type) natriuretic peptide (NT-proBNP) is produced predominately by the cardiac ventricular myocytes. It is released in response to volume expansion and filling pressure and is involved in maintaining intravascular volume homeostasis. After synthesis, the peptide is cleaved first to proBNP and subsequently to BNP (active form) and NT-proBNP (inactive form).

Natriuretic peptide (NP) levels (BNP and NT-proBNP) are widely used in clinical practice and cardiovascular research as a diagnotic tool for the occurrence and severity of heart failure (HF) and coronary syndrome.

Elevated plasma levels of BNP and NT-proBNP have been observed at times of cardiac stress and damage. It has also been shown that increased NP values in patients with renal dysfunction can suggest the presence of cardiac disease. Low circulating NP levels have been observed in obese people, however the prognostic capacity of these biomarkers were not affected for those patients.

In summary, NP levels are quantitative plasma biomarkers of an accurate diagnosis of heart failure. Measurements of NP levels may help in risk stratification of patients suffering heart attacks in emergency care and in accurate and rapid diagnosis of heart failure in primary care.

Packing Contents

Individually pouched test devices

Package insert

Assay Buffer

Droppers

Test Procedure

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