Lactoferrin Rapid Test

Intended Use

Lactoferrin Rapid Test (Feces) is a rapid visual immunoassay for the qualitative, the qualitative detection of human lactoferrin in feces samples that may reflect intestinal inflammation in inflammatory bowel disease (IBD).

Introduction

Lactoferrin(LF) is a glycoprotein that is produced by neutrophils, mononuclear phagocytes and epithelial cells and is contained in the secretory fluids such as saliva and breast milk. Its function is to block bacterial growth by limiting the availability of iron and this effect is enhanced by the presence of specific secretory IgA antibodies directed against bacteria. LF also has a bacteriocidal effect by causing direct damage to cell membranes in cooperation with lisozyme. When inflammation develops in the gastrointestinal tract, neutrophils and phagocytic cells migrate to the inflammatory focus and release the granules containing Lf. Lf is stable in faeces and is easily detected for immunochemical methods.

What we should know about the Lactoferrin Rapid Test (Feces)?

1. Lactoferrin Rapid Test must be carried out within 2 hours of opening the sealed bag.

2. An excess of stool sample could result in wrong results (brown bands appear or absence of the control colored band).

3. Stool from patients with active inflammatory bowel diseases that usually involve significant neutrophilic inflammation of the instestine, such as Crohn's disease and ulcerative colitis, would be positive for fecal lactoferrin. Lactoferrin Rapid Test could be sensitive for this diagnosis in patients with chronic diarrhea.

4. Positive results confirm the presence of human lactoferrin in fecal samples; nevertheless, it can be also due to several causes besides IBD. A positive result should be followed up with additional diagnostic procedures. Endoscopy and histology on biopsy specimens are the methods for detecting and quantifying bowel inflammation.

5. Negative results do not exclude inflammation, some diseases such as celiac sprue and microscopic colitis polyps that involve mainly monocuclear inflammation.

6. Lactoferrin is a component of breast milk; the test will be positive in breast fed children and should not be used to evaluate neonates receiving breast milk.

Test Procedure

Hot Tags: lactoferrin rapid test, China, suppliers, manufacturers, factory, bulk, Lactoferrin Rapid Test, Alpha fetoprotein Rapid Test, High Level Ferritin Rapid Test, Prostate Specific Antigen Rapid Test Device, Carcinoembryonic Antigen Rapid Test, Faecal Occult Blood Rapid Test